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There have been efforts to address it, including involving single-cell approaches, for example by characterizing heterogeneous single-cell dose responses (Kinnunen et al
That is the core promise of Dihexa, one of the most potent and intriguing experimental neuropeptides to emerge from academic research in recent years
doi: 10.1186/1475-2891-3-5 193 LorzadehEHeidaryZMohammadiMNadjarzadehARamezani-JolfaieNSalehi-AbargoueiA
The intranasal GHK-Cu treatment was found to delay cognitive impairment, reduce amyloid plaques, and lower inflammation levels in the frontal cortex and hippocampus .37 Randomized controlled trials in human patients are needed to confirm the benefit of GHK-Cu for cognitive decline and Alzheimers disease as well as to evaluate safe and effective human dosing (the human dose equivalent of 15mg/kg in mice would be ~1.2mg/kg, though data on this or any other dosing nasally in humans is not currently available), but preliminary animal trials are promising
Roark, K
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