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Currently, common clinical GLP-1RAs include exenatide and exenatide-LAR [34,35,36,37,38,39,40], lixisenatide [41,42,43,44], beinaglutide [45], liraglutide [46,47,48,49,50,51,52,53], semaglutide [54,55,56,57,58], albiglutide [59,60,61], dulaglutide [62,63,64], oral semaglutide [58, 65,66,67], PEG-loxenatide [68] and tirzepatide [68,69,70,71,72,73] (Table 1)
DAF-FM diacetate for FCM
There was no apparent effect of renal impairment, hepatic impairment or upper GI disease on the PK and tolerability of orally administered semaglutide, suggesting that dose adjustment is not necessary in these special populations [11, 31,32,33]
