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According to a 2022 review, gastrointestinal side effects, including constipation, were among the most commonly reported adverse effects of GLP-1 receptor agonists, especially during the dose-escalation phase in about 25-35% of users

As shown in Figure 5A, as the concentration of methylglyoxal increased, PC12 cell viability gradually decreased, and the cell viability dropped to approximately 50% at the methylglyoxal dose of 2.0 mM

Daily intraperitoneal administration for 11 days reduced body weight gain, decreased white adipose tissue mass by approximately 35%, and reduced adipocyte size, while food intake between treated and control groups did not differ significantly

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Antibacterial agent 318 acts as an oxidative stress inducer, elevating intracellular reactive oxygen species (ROS) levels, oxidizing glutathione (GSH) to glutathione disulfide (GSSG), depleting cellular GSH reserves, and inducing bacterial cell death through oxidative damage