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Description

[1] When combined, the cumulative effect on heart rate and blood pressure may be clinically significant, particularly in patients with pre-existing cardiovascular disease, uncontrolled hypertension, or arrhythmias

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Leininger-Muller B, Ghersi-Egea JF, Siest G, Minn A

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linagliptin needs no renal adjustment Limitations & safety Cardiovascular outcome trials (CVOTs) PBS rules (Authority Required Streamlined) Must be used with metformin sulfonylurea and/or insulin

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Al-Najim W, Raposo A, BinMowyna MN, le Roux CW

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