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Insulin has stimulatory effects on ovarian androgen production 5,11 , and enhances the bioavailability of testosterone by decreasing the hepatic release of sex hormone-binding globulin (SHBG) 12
In many autoimmune conditions, the immune system stays overactive and causes inflammation
doi: 10.1016/j.molmet.2018.09.009 45 GarveyWTFriasJPJastreboffAMle RouxCWSattarNAizenbergDet al
You should contact your GP urgently if sleep disturbances are accompanied by: Severe or persistent gastrointestinal symptoms such as unrelenting nausea, repeated vomiting, severe abdominal pain, or signs of dehydration (extreme thirst, dry mouth, reduced urination, dizziness) Symptoms suggestive of pancreatitis , including severe upper abdominal pain radiating to the back, particularly if associated with nausea and vomiting [14] [15] Right upper abdominal pain, fever or yellowing of the skin or eyes , which could indicate gallbladder problems [1] [2] Significant mood changes or thoughts of self-harm (while a causal link between GLP-1/GIP agonists and mood changes is not established, seek urgent help for such symptoms regardless of cause) [18] [19] Symptoms of hypoglycaemia (if taking Mounjaro alongside insulin or sulfonylureas), such as night sweats, nightmares, or morning headaches [12] Unexplained rapid heart rate or palpitations that disturb sleep Your GP can conduct a thorough assessment to determine whether sleep problems are directly related to Mounjaro, secondary to its side effects, or due to other factors such as sleep apnoea, restless legs syndrome, or mental health concerns
