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Current DAMP/PRR-targeted therapeutic strategies are comprehensively reviewed, including: modulating cell death pathways to reduce DAMP release, neutralizing DAMP activity using monoclonal antibodies, developing small-molecule inhibitors to block signaling pathways, and employing enzymatic degradation or gene silencing technologies for precise intervention
246 The immune aging process results in functional alterations in immune cells, increasing the susceptibility of elderly individuals to metabolic dysfunction
Lindeberg M
doi: 10.1093/brain/awaa262
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