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The following reagents were procured from Beyotime Institute of Biotechnology (Shanghai, China): mitochondrion-selective probe (Mito-Tracker Green), DCFH-DA, mitochondrial membrane potential assay kit (JC-1), Annexin V-FITC/propidium iodide (PI) apoptosis and necrosis detection kit, H&E staining kit, and One Step TUNEL Apoptosis Assay Kit
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This article systematically reviews the substantial impacts of LAB on macrophages, including effects on macrophage quantity, polarization, autophagy, apoptosis, metabolism, trained immunity, and so on, which contribute to the control of disease progression
Other forms exist on the market, including NR hydrogen malate, but these boast too little research in humans to verify their safety and efficacy
It works holistically, targeting the root causes of cognitive challenges rather than just masking symptoms
doi: 10.1016/j.bpsc.2021.11.014
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