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Adverse reaction 1) If overdose, the following adverse reactions may occur: Headache, asthenia, fatigue, muscle pain, Loss of appetite, weight loss, growth disorder, nausea, vomiting, constipation, diarrhea, polydipsia, polyuria, dehydration, high blood pressure, calcium oxalate stones, tissue calcification, kidney disease, vascular disease, and kidney failure

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Without glutathiones facilitation, these enzymes would be unable to catalyze essential antioxidant processes

Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above