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Collectively, these findings highlight the multifaceted role of BHB in metabolic regulation and signal transduction, underscoring its importance in maintaining homeostasis and potentially in the treatment of various diseases
this rules out the non-specific effects of confounders in HFD-fed mice
Recent research determined that chronic alcohol intake inhibited the activation of mammalian target of rapamycin complex 1 (mTORC1), leading to an uncoupling status between lipolysis and the browning/thermogenesis of white adipose tissue (WAT), and thus exacerbating hepatic lipid accumulation, inflammation, and fibrosis in the development and progression of ALD (Song et al., 2023)
Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
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