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CJC-1295 binds to GHRH receptors, increasing the baseline signal for growth hormone production Ipamorelin binds to ghrelin receptors, amplifying the pulse on top of CJC-1295's baseline elevation When both pathways are activated simultaneously, the growth hormone response is significantly greater than either peptide alone a true synergistic effect, not merely additive
Wang R, Lagakos SW, Ware JH, et al
Technique matters: Let injection reach room temperature (30 minutes out of fridge)
Risks of continuing GLP-1RA during the perioperative period GLP-1 agonists are known to enhance gastroparesis, and there are legitimate concerns for aspiration during the induction of general anaesthesia
That is meaningful, sustained fat loss, not just water
