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Dermatologists have documented the darkening and rapid change of existing moles, the eruption of new melanocytic nevi, and multiple instances of melanoma or melanoma in situ arising in people using Melanotan 2 with the important caveat that a temporal association in a case report does not establish that the drug caused the cancer

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This observation led to the creation of PT-141 as a more targeted compound, eventually culminating in FDA approval as Vyleesi for hypoactive sexual desire disorder in 2019

These factors exist independently of semaglutide and would be present whether or not GLP-1 therapy was part of the treatment plan

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