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Endoscopy: If intrinsic factor deficiency is suspected, your healthcare provider may conduct an endoscopy to examine the stomach lining and identify potential causes of reduced inherent factor production

Johnson, W., Bergfeld, W

That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

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