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Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach

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doi: 10.1038/s41422-021-00569-8

Pyroptosis: a new paradigm of cell death for fighting against cancer

Medullary thyroid carcinoma is a rare form of thyroid cancer, accounting for approximately 3-4% of all thyroid malignancies in the United States