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Variability-accommodating pharmacodynamics (time-integrated effects): When pharmacodynamic effects integrate over time and depend on the area under the curve (AUC) or sustained receptor occupancy rather than peak concentration, transient fluctuations in plasma concentration have limited clinical consequences

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Insulin and sulfonylureas: Semaglutide increases the risk of hypoglycemia when used with other medication used to control hyperglycemia

By increasing eumelanin production in individuals with low baseline pigmentation, afamelanotide addresses a biological vulnerability

(LaRoche 2018) Observe for recurrent seizures