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51 The impact of GLP-1RAs on patients with obesity and HFpEF was recently demonstrated in the STEP HFpEF trial
When compared to GLP-1 receptor agonists alone, DA-CH5 had greater neuroprotection than exendin-4 [110], whilst DA-CH3 protected dopaminergic neurons, reduced inflammation, and MPTP-induced motor impairment to a greater extent than liraglutide [115]
Subsequently, an oral formulation for once-daily administration (Rybelsus , Novo Nordisk) was developed in 2019 to treat type 2 diabetes
But equally, in todays anti-ultra-processed food (UPF) climate, the consultant warns against adding unnecessary additives
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