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The new hypothesis says GIP and glucagon may have been doing the heavier lifting all along, and the GLP-1 arm which drives the side effects may be optional

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Combining them, NAD+ therapy restores levels while 5-Amino-1MQ prevents rapid depletion, enhancing longevity for those over 40.[7][36][37][38] This synergy addresses both supply and conservation, leading to amplified effects on energy metabolism

Perspectives in Biology and Medicine