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Role of AP1 binding site contained within human antioxidant response element
It does not cause clinically significant changes in blood pressure or prolong the QT interval, meaning it lacks a hypertension warning and can be safely used in patients with pre-existing hypertension (Staskin et al 2024)
doi: 10.1016/S2213-8587(17)30085-2 61 GersteinHCSattarNRosenstockJRamasundarahettigeCPratleyRLopesRDet al
But tirzepatide is a potent dual GLP-1/GIP receptor agonist that affects multiple body systems simultaneously
Biased Agonism at the GLP-1R Tirzepatide displays unique pharmacology and is described as an imbalanced agonist
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