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Long-term administration in mice inhibited development of leukemia by 6-fold and reduced total spontaneous tumor incidence, with no increase in cancer risk despite telomerase activationaddressing theoretical concerns about uncontrolled proliferation
The association was strongest at weight-loss dosages and with longer treatment duration
He, C., Tsend-Ayush, E., Myers, M
It is based on receptor biology, animal studies, and early clinical data that point in a consistent direction
Phase Phase 3 Mid escalation Weeks Weeks 912 Dose 7.5 mg once weekly Notes Transitional
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