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This may be more likely in people following vegan diets, some vegetarian diets or diets with limited animal products

To test whether the effects of GLP-1(2836) require its ability to interact with MTP, we knocked down MTP expression using a siRNA and repeated our Seahorse experiments

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If anyone gives a more specific answer than that, its an educated guess based on early trial data and what we know about similar drugs

Genetics: Variations in hormone receptor sensitivity and metabolic rate may affect response to triple agonist therapy, though evidence on genetic predictors is currently limited and emerging