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In-depth analysis of tandem mass spectrometry data from disparate instrument types
Doi: 10.1371/journal.pone.0210389
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The principal active ingredients are withanolides, a class of steroidal lactones, which are regarded as the primary agents responsible for its neuroprotective and psychotropic effects (75)
While CBP/p300 is a well-validated direct interaction partner of NRF2 with prominent functions at enhancers, we report that this interaction is not required for NRF2-dependent NSCLC cell growth, indicating that NRF2 can sustain sufficient transcriptional activity in the absence of CBP/p300 coactivation
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