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Heres a simple way to picture insulin resistance: think of insulin as traffic police managing the flow of sugar (glucose) from your blood into your bodys cells, like a highway

Diabetologia 65(Suppl 1):S290S291 Gastaldelli A, Cusi K, Fernandez Lando L, Bray R, Brouwers B, Rodriguez A (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

This specific biochemical modification creates a highly stable, lipophilic (fat-soluble) shield around the molecule

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Persistent or severe symptoms: Nausea, vomiting, or headaches that last for more than a few days or are unusually intense