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In HNSCC, in vitro knockdown of SMAD 4 induced cetuximab resistance by activating TGF- and c-MET pathways [99]
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It modulates gene expression linked to tissue remodeling and exerts antioxidant and anti-inflammatory effects through TGF- and metalloproteinase regulation
However, a doseresponse analysis found that above 60 g of daily dietary selenium intake was associated with a higher risk of type 2 diabetes (30), and supplementary 200 g/day of selenium intake could also have a linear relationship with diabetes incidence in Western participants (31)
Elevated levels warn of excessive resorption long before fractures occur or density loss becomes severe
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