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A 30-min permeability test for SF and EBA markers performed after the 24-h nanocarrier permeability assays confirmed that the integrity of the BBB models was preserved and the nanocarriers had no barrier damaging effect (Table S2)
This reduction slows basal metabolic rate by 10-15% in some individuals, significantly narrowing the caloric deficit that produced initial weight loss
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In contrast, although TH exhibited minimal coexpression with PrRP in the AP (Figure 8G), the majority of NTS PrRP-positive neurons also expressed TH (Figure 8H)
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