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Although redressing the BA composition has proved to be beneficial in mouse models, it was unlikely to translate to human pathophysiology, as changes in BA composition in mice hardly reflect similar changes in BA profiles in humans due to the differences in BA composition 41

This leads to poor data consistency and limited reproducibility

ALC may also reduce blood sugar, blood pressure and inflammation, all of which are associated with the development of age-related chronic disease

Melatonin is most useful for circadian rhythm disruption and difficulty falling asleep, less so for middle-of-night awakenings