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It plays several important roles in how your body manages energy: It signals your pancreas to release insulin when blood sugar rises It slows the rate at which food leaves your stomach, making you feel full longer It acts on the brains hunger centers to reduce appetite and food cravings It lowers glucagon, a hormone that triggers the liver to release stored sugar GLP-1 receptor agonists are medications that mimic and amplify these effects

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Elsevier, Amsterdam, pp 382390

DM is closely linked with gradual and sustained damage to different organs, especially the nerves, kidneys, eyes, heart and blood vessels