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Additionally, it was reported that trimetazidine (TMZ), a piperazine derivative, mediated activation of the GSH system and had antioxidant and cytoprotective effects in several myocardial injury models [210,211,212,213]

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In human trials involving women with photoaged skin, it increased skin density and thickness, decreased laxity, improved firmness and clarity, and reduced fine lines and wrinkle depth [9]