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On April 30, 2026, the FDA proposed to exclude semaglutide, tirzepatide, and liraglutide from the 503B bulks list entirely, citing no clinical need for large-scale compounding now that FDA-approved supply is stable
The practical reality is that differences in anti-inflammatory effects between GLP-1 receptor agonists are likely modest and may be overshadowed by individual patient response, tolerability, and the degree of metabolic improvement achieved
This means more people can stay on tirzepatide at effective doses compared to semaglutide, which is a meaningful advantage when the goal is long-term use
