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Contact your GP or healthcare provider if you experience: Dark amber or brown urine persisting despite increased fluid intake, which may indicate severe dehydration or, rarely, liver dysfunction Urine colour changes accompanied by symptoms such as persistent vomiting, inability to tolerate oral fluids, severe diarrhoea, or abdominal pain Signs of dehydration : Dizziness, lightheadedness, dry mouth, passing urine less often than usual, dark or strong-smelling urine, or rapid heartbeat Red, pink, or cola-coloured urine : May indicate haematuria (blood in urine), requiring investigation for urinary tract pathology Cloudy or foul-smelling urine with dysuria : Suggests possible urinary tract infection Pale or clay-coloured stools with dark urine and jaundice : Rare but serious indicators of biliary obstruction or hepatic dysfunction For urgent advice : Contact NHS 111 if you cannot reach your GP and need help quickly

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Resources: GLP-1 Agonists Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes Safety of Semaglutide Once-Weekly Semaglutide in Adults with Overweight or Obesity Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes Semaglutide vs Tirzepatide for Weight Loss in Adults With Overweight or Obesity Medication-Induced Gastroparesis: A Case Report Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASSCVOT design and baseline characteristics Tirzepatide for the treatment of obstructive sleep apnea: Rationale, design, and sample baseline characteristics of the SURMOUNT -OSA phase 3 trial Tirzepatide prevents neurodegeneration through multiple molecular pathways TripleHormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial Biology of Incretins: GLP-1 and GIP GIP and GLP1, the two incretin hormones: Similarities and differences GLP-1, GIP and glucagon receptor poly-agonists: A new era in obesity pharmacotherapy

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