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Furthermore, B1 derived IgM antibodies exhibit both direct and indirect anti-inflammatory activities and are considered to protect against diet-induced chronic inflammation in some cases (146148)

The authors themselves described it as a small preliminary study.[15] A 2025 pilot report described intravenous administration to two healthy adults at doses up to 20 mg, with no measurable changes in cardiac, hepatic, renal or thyroid biomarkers and no reported adverse effects.[16] Two individuals cannot characterise uncommon reactions, immunogenicity, long-term toxicity, reproductive safety or oncological risk

Guo J, Liu G, Guo G

Large human trials and better active surveillance would help answer these questions