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TABLE 1 Clinical studies of GLP-1RA in liver diseases

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Sources: Sonthalia et al., 2018 , Narrative review, 2025 Precautions before treatment Disclose your full medical history, medicines and supplements Get a personalised dose and route from a qualified doctor Avoid if pregnant or breastfeeding Flag any known allergies or sensitivities Self-medication or IV use without medical supervision can pose serious health risks

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Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue