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The GTP-bound alpha subunit can move away and activate downstream pathways, and the beta and gamma subunits can also dissociate and trigger complementary pathways

Ozdemir Kutbay et al

A rat retinal ischemia study was conducted throughout 4 weeks, including fundoscopy, behavior presentation, tonometry, and histology assessment

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While most control Fbxl5 F/F mice survived, over half of FBXL5 CD11c mice died within 48 h when challenged with a higher dose of APAP (500 mg/kg) (Fig