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Including enhancement of nucleotide excision repair capacity in melanocytes and keratinocytes following MT-1 treatment, reduction of UV-induced cyclobutane pyrimidine dimer formation, activation of antioxidant defence pathways, and upregulation of DNA repair enzyme expression downstream of MC1R-cAMP signalling
Broglio F, Gottero C, Prodam F, et al
Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk
What is a GST pull-down assay
M.VerbeekM
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