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As the supply shortfall has driven explosive growth in the black market for GLP-1 drugs, the FDA has temporarily allowed production of what are known as compounded versions of the drugs

However, it seems prudent to advise added caution for patients taking semaglutide or those who are considering starting this medication if they have experienced visual loss from any cause, the editorial concluded

These modifications make it more stable and resistant to enzymatic degradation compared to native GLP-1, allowing for prolonged activity in vitro and in vivo models

GI Tolerability (Future) MariTide Phase 2 data showed GI side effects were predominantly mild, transient, and concentrated at the first dose, suggesting potentially better long-term GI tolerability compared to weekly incretin injections

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