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Phentermine is a stimulant appetite suppressant a cheap, oral, generic Schedule IV controlled substance FDA-approved for short-term use (generally up to 12 weeks)

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The clinical evidence base for tirzepatide as a GLP-1+GIP agonist is similarly strong, with trial data showing substantial weight reduction in studied populations

In the gastrointestinal system, GLP-1 receptor agonists slow gastric emptying, meaning food remains in the stomach for longer periods