The GLP-1 class now includes multiple options at Defiance Health: Semaglutide (generic compounded, Wegovy, Ozempic) the original weight loss GLP-1, delivering 15-17% body weight loss on average at maintenance doses Tirzepatide (generic compounded, Zepbound, Mounjaro) a dual GIP/GLP-1 agonist, typically delivering 20-22% body weight loss at the highest dose Foundayo (orforglipron) FDA-approved April 1, 2026 , the first non-peptide GLP-1 pill that can be taken any time of day, with or without food
In preclinical studies conducted on cynomolgus monkeys it has shown agonistic activity to human and cynomolgus GLP-1 receptors and improved glucose tolerance by stimulating insulin secretion, and it exhibited an anti-feeding activity like exenatide
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For researchers weighing over 300 pounds (136 kg), the standard 4-week escalation is typically well tolerated, and the 12mg maintenance dose is strongly recommended
