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This approach helps maintain pituitary sensitivity to the compound
SURMOUNT-5 was a phase 3b randomized controlled trial conducted at 32 sites across the United States and Puerto Rico.[1] A total of 751 adults with obesity but without type 2 diabetes were randomly assigned to receive either tirzepatide or semaglutide once weekly by subcutaneous injection for 72 weeks, which is just under 17 months.[1] Both medications were increased to the maximum tolerated dose
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