Kenneth Custer, head of cardiometabolic health at Lilly, said that with Zepbound, Foundayo and retatrutide, the company can "match treatments to the needs and preferences of patientsacross various stages of their obesity journey." The company is thought to be waiting for the results of two more trials later this year TRIUMPH-2 in obesity or overweight and type 2 diabetes, and TRIUMPH-3 in obesity or overweight and established cardiovascular disease before filing retatrutide for approval in late 2027 or early 2028.
While retatrutide is being rolled out, you can still make progress on your weight loss goals with proven treatments like semaglutide and tirzepatide
Other providers might transition more directly
Larazotide is formulated to act locally in the gut lumen with minimal systemic absorption, which simplifies some aspects of CMC and safety, but also limits its reach to the GI tract
That drop in energy can make it harder to stay active, exercise, and follow through on healthy routines