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The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

However, selenium supplementation is not routinely recommended in UK guidance, and should only be considered under clinician advice due to limited evidence for clinical benefit and potential toxicity risk

For researchers who want clean GH stimulation without managing multiple elevated side-hormones, Ipamorelin is the most studied choice

This mirrors physiologic pulsatility more closely than continuous GH infusion

Start (Weeks 12): 20 mcg daily to assess tolerance, particularly regarding blood glucose effects [6]