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To test the effect of sustained repression of lipogenic programs and a concurrent sustained induction of NRF2 activity, we monitored mice for ten weeks following the induction of Gclc deletion alone (Gclc L-KO) or in combination with Nrf2 deletion (L-DKO) in the liver (Fig
found that GLP-1 receptor agonist use, compared with initiation of sodium-glucose cotransporter 2 (SGLT2) inhibitors, was associated with a lower risk of composite MALOs (aHR: 0.84, 95%CI: 0.74-0.94), including specifically lower occurrence of liver decompensation (aHR: 0.83) and all-cause mortality (aHR: 0.84) [56]
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SURMOUNT-MAINTAIN (Horn 2026, 112 weeks): continued top dose -21.9% vs 5 mg step-down -16.6% vs placebo -9.9%, rescue therapy 8/25/67%: Aronne JAMA 2024
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