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Consequently, a vicious cycle of oxidative stress and inflammation is formed, leading to chronic tissue damage, cell death, and the progression of various diseases

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1 DR DR is strongly related to the duration of diabetes, the level of glycemic control, nephropathy, hypertension and dyslipidemia and contributes to the disruption of the blood-retinal barrier (BRB), which is mainly caused by VEGF-A and proinflammatory factors

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