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The figure shows robust expression of ZO-1 in epithelial enterocytes of small intestinal organoids (which is diminished under CARD9-inhibited conditions)

37,38 Numerous studies have shown the significance of SOCS3 in establishing the degree of leptin sensitivity

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This heterogeneity and poorly understood neurobiology pose significant challenges to existing drug development paradigms, resulting in scarce treatment options, especially for bipolar depression