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There are plenty of relevant studies on linkage between MTHFR and human diseases including cardiovascular diseases, tumors, neurologic diseases, and psychiatric disorders 2,3,4,5

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For example, a 2019 study of over 9,000 adults found people with obesity had lower blood levels of vitamin B12 (8)

This mechanism explains the peptides remarkable effects across tendons, ligaments, muscle tissue, gastrointestinal conditions, and nerve damage documented in 35 preclinical studies spanning three decades