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GHK-Cu (sister peptide) given as repeated 2 mg injections into rat wound chambers modulated decorin/biglycan and increased type-I collagen and GAGs grounds the milligram-per-injection magnitude sometimes cited for the class, but this is GHK-Cu, rat, wound-healing

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Increases in cGMP result in the inhibition of plasma membrane localized L-type Ca 2+ channels resulting in decreasing overall intracellular Ca 2+ which normally serves to activate myosin light chain kinase leading to vasoconstriction