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While fatigue is not among the most frequently reported adverse reactions in clinical trials, some patients do experience tiredness or low energy during treatment

They have been shown to lower the risk of heart attack by 23% and stroke by 17%, are remarkably safe, and remarkably cheap, costing as little as $10 per month

Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

Whether this translates to meaningfully better lean mass outcomes in clinical practice is still being investigated across the ongoing REDEFINE program