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It was found that higher prevalence of Akkermansia levels in the gut microbiota are inversely related to insulin sensitivity, fasting glucose, waist-to-hip ratio, body fat mass, and plasma triglycerides, corroborating previous evidence in mice of the effects of Akkermansia for regulating metabolism

Additionally, GLP-1 receptor agonists slow gastric emptying, which prolongs the feeling of fullness after eating, and they act on appetite centres in the hypothalamus to reduce hunger and food intake

doi:10.1016/j.phrs.2022.106320 101

It may be appropriate for patients who have previously tolerated similar medications well and are known to have low sensitivity to GI-related side effects

Chambers AP, et al