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But the scale refuses to budge, and hunger that disappeared months ago starts creeping back between meals

If someone is admitted for exacerbation of heart failure, theyre leaving the hospital with five medicines, all guideline-directed

Plus, their fiber is harder to break down, so they travel all the way through the GI tract, "reaching the large intestine where gut bacteria feed on it, producing compounds called short-chain fatty acids, which also produce GLP-1," notes Younkin

StatPearls, NCBI Bookshelf

On the special, Winfrey invited medical professionals to discuss how the drugs worked and why obesity is a disease, not a character flaw