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Interestingly, the effect of metformin on gut glucose utilisation is well known to radiologists, as metformin use will interfere with imaging by positron emission tomographycomputed tomography (PET-CT)
These may include: Nausea (most commonly reported, particularly during dose titration) Vomiting Diarrhea or constipation Decreased appetite Bloating or abdominal discomfort For many patients, these effects are most noticeable when starting or adjusting the dose, and they often improve over time
therefore, it may go unnoticed that aberrations in the promotor function of the SWI/SNF complex generate vulnerabilities that attenuate transcription
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