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This distinction is important, and your physician should discuss it with you as part of informed consent

Manganese peptide complexes (e.g., manganese tripeptide-1) have been explored as alternatives that avoid copper-related skin discoloration concerns while providing metal-dependent enzymatic activation

Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System, Sikiric P, Seiwerth S, Skrtic A, Staresinic M, Strbe S, Vuksic A, Sikiric S, Bekic D, Soldo D, Grizelj B, Novosel L, Beketic Oreskovic L, Oreskovic I, Stupnisek M, Boban Blagaic A, Dobric I, Pharmaceuticals (Basel), Pharmaceuticals, 2025 Jun 19;18(6):928

But while FDA approval may help reduce some of those risks, other commenters said it could create new ones

Mu, Q., Kirby, J., Reilly, C