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This article is part of the PlexusDx Education Hub, a library of evidence-based guidance on GLP-1 therapies, weight-management protocols, and the genetic factors that shape metabolic care

Most people did fine on semaglutide

Follow Directions: Always take medications as directed on the label or by your doctor to ensure safety and effectiveness

The effect sizes were modest but consistent

The implication is that more agonism is better is going to age very poorly as a default assumption, and any clinician or biohacker still defaulting to it in 2030 is going to look like the cardiologists who were still reaching for first-generation beta-blockers in 1995