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Combination therapies, such as Miltefosine with Paromomycin or liposomal Amphotericin B, are also being investigated to improve effectiveness and reduce treatment duration ( Nanoparticle formulations of Amphotericin B, including topical options, are being trialed for safer, localized treatment of CL lesions ( 7 Emerging drug targets in Leishmania Recent advances in molecular and cellular biology have identified several promising drug targets that could pave the way for novel therapeutic interventions ( Leishmania parasites, suggesting its potential as a therapeutic target for visceral leishmaniasis (Wyllie et al., 2018)

Rinaldi R, De Nucci S, Castellana F, Di Chito M, Giannuzzi V, Shahini E, Zupo R, Lampignano L, Piazzolla G, Triggiani V, et al

Respecto al anlisis de correlacin hubo una relacin positiva para las variables antropomtricas de peso seco, talla y rea muscular de brazo con la creatinina final

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This causes the stone to break into smaller fragments that can then pass more easily